A superior extracellular matrix binding motif to enhance the regenerative activity and safety of therapeutic proteins.

ABSTRACT: Among therapeutic proteins, cytokines and growth factors have great potential for regenerative medicine applications. However, these molecules have encountered limited clinical success due to low effectiveness and major safety concerns, highlighting the need to develop better approaches that increase efficacy and safety. Promising approaches leverage how the extracellular matrix (ECM) controls the activity of these molecules during tissue healing. Using a protein motif screening strategy, we discovered that amphiregulin possesses an exceptionally strong binding motif for ECM components. We used this motif to confer the pro-regenerative therapeutics platelet-derived growth factor-BB (PDGF-BB) and interleukin-1 receptor antagonist (IL-1Ra) a very high affinity to the ECM. In mouse models, th

SUBMITTER: Alshoubaki YK 

PROVIDER: S-EPMC10202959 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature