Clinicopathological and ultrasound characteristics of breast cancer in BRCA1 and BRCA2 mutation carriers.

ABSTRACT:

Purpose

BRCA1 and BRCA2 tumors exhibit different characteristics. This study aimed to assess and compare the ultrasound findings and pathologic features of BRCA1 and BRCA2 breast cancers. To our knowledge, this is the first study to examine the mass formation, vascularity, and elasticity in breast cancers of BRCA-positive Japanese women.

Methods

We identified patients with breast cancer harboring BRCA1 or BRCA2 mutations. After excluding patients who underwent chemotherapy or surgery before the ultrasound, we evaluated 89 cancers in BRCA1-positive and 83 in BRCA2-positive patients. The ultrasound images were reviewed by three radiologists in consensus. Imaging features, including vascularity and elasticity, were assessed. Pathological data, including tumor subtypes, were rev

SUBMITTER: Ikejima K 

PROVIDER: S-EPMC10202977 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature