Maternal HIV infection drives altered placental Mtb-specific antibody transfer.

ABSTRACT:

Introduction

Placental transfer of maternal antibodies is essential for neonatal immunity over the first months of life. In the setting of maternal HIV infection, HIV-exposed uninfected (HEU) infants are at higher risk of developing severe infections, including active tuberculosis (TB). Given our emerging appreciation for the potential role of antibodies in the control of Mycobacterium tuberculosis (Mtb), the bacteria that causes TB, here we aimed to determine whether maternal HIV status altered the quality of Mtb-specific placental antibody transfer.

Methods

Antigen-specific antibody systems serology was performed to comprehensively characterize the Mtb-specific humoral immune response in maternal and umbilical cord blood from HIV infected and un

SUBMITTER: Nziza N 

PROVIDER: S-EPMC10203169 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature