The Tacrolimus Concentration/Dose Ratio Does Not Predict Early Complications After Kidney Transplantation.

ABSTRACT: Early-on post kidney transplantation, there is a high risk of graft rejection and opportunistic viral infections. A low tacrolimus concentration/dose (C/D) ratio as a surrogate marker of fast tacrolimus metabolism has been established for risk stratification 3 months post-transplantation (M3). However, many adverse events occurring earlier might be missed, and stratification at 1 month post-transplantation (M1) has not been investigated. We retrospectively analyzed case data from 589 patients who had undergone kidney transplantation between 2011 and 2021 at three German transplant centers. Tacrolimus metabolism was estimated by use of the C/D ratio at M1, M3, M6, and M12. C/D ratios increased substantially during the year, particularly between M1 and M3. Many viral infections and most graf

SUBMITTER: von Samson-Himmelstjerna FA 

PROVIDER: S-EPMC10203205 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature