Functional specialization and interaction in the amygdala-hippocampus circuit during working memory processing.

ABSTRACT: Both the hippocampus and amygdala are involved in working memory (WM) processing. However, their specific role in WM is still an open question. Here, we simultaneously recorded intracranial EEG from the amygdala and hippocampus of epilepsy patients while performing a WM task, and compared their representation patterns during the encoding and maintenance periods. By combining multivariate representational analysis and connectivity analyses with machine learning methods, our results revealed a functional specialization of the amygdala-hippocampal circuit: The mnemonic representations in the amygdala were highly distinct and decreased from encoding to maintenance. The hippocampal representations, however, were more similar across different items but remained stable in the absence of the stimu

SUBMITTER: Li J 

PROVIDER: S-EPMC10203226 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature