Ligand impact on reactive oxygen species generation of Au₁₀ and Au₂₅ nanoclusters upon one- and two-photon excitation.

ABSTRACT: In photodynamic therapy (PDT), light-sensitive photosensitizers produce reactive oxygen species (ROS) after irradiation in the presence of oxygen. Atomically-precise thiolate-protected gold nanoclusters are molecule-like nanostructures with discrete energy levels presenting long lifetimes, surface biofunctionality, and strong near-infrared excitation ideal for ROS generation in PDT. We directly compare thiolate-gold macromolecular complexes (Au₁₀) and atomically-precise gold nanoclusters (Au₂₅), and investigate the influence of ligands on their photoexcitation. With the ability of atomically-precise nanochemistry, we produce Au₁₀SG₁₀, Au₁₀AcCys₁₀, Au₂₅SG₁₈, and Au₂₅AcCys₁₈ (SG: glu

SUBMITTER: Fakhouri H 

PROVIDER: S-EPMC10203263 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature