Wetting and complex remodeling of membranes by biomolecular condensates.

ABSTRACT: Cells compartmentalize parts of their interiors into liquid-like condensates, which can be reconstituted in vitro. Although these condensates interact with membrane-bound organelles, their potential for membrane remodeling and the underlying mechanisms of such interactions are not well-understood. Here, we demonstrate that interactions between protein condensates - including hollow ones, and membranes can lead to remarkable morphological transformations and provide a theoretical framework to describe them. Modulation of solution salinity or membrane composition drives the condensate-membrane system through two wetting transitions, from dewetting, through a broad regime of partial wetting, to complete wetting. When sufficient membrane area is available, fingering or ruffling of the condensa

SUBMITTER: Mangiarotti A 

PROVIDER: S-EPMC10203268 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature