Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease.

ABSTRACT:

Background

Epigenetic dysregulation has been proposed as a key mechanism for arsenic-related cardiovascular disease (CVD). We evaluated differentially methylated positions (DMPs) as potential mediators on the association between arsenic and CVD.

Methods

Blood DNA methylation was measured in 2321 participants (mean age 56.2, 58.6% women) of the Strong Heart Study, a prospective cohort of American Indians. Urinary arsenic species were measured using high-performance liquid chromatography coupled to inductively coupled plasma mass spectrometry. We identified DMPs that are potential mediators between arsenic and CVD. In a cross-species analysis, we compared those DMPs with differential liver DNA methylation following early-life arsenic exposure in the apoE knockout (apoE^-/-

SUBMITTER: Domingo-Relloso A 

PROVIDER: S-EPMC10203287 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature