A blood and bronchoalveolar lavage protein signature of rapid FEV₁ decline in smoking-associated COPD.

ABSTRACT: Accelerated progression of chronic obstructive pulmonary disease (COPD) is associated with increased risks of hospitalization and death. Prognostic insights into mechanisms and markers of progression could facilitate development of disease-modifying therapies. Although individual biomarkers exhibit some predictive value, performance is modest and their univariate nature limits network-level insights. To overcome these limitations and gain insights into early pathways associated with rapid progression, we measured 1305 peripheral blood and 48 bronchoalveolar lavage proteins in individuals with COPD [n = 45, mean initial forced expiratory volume in one second (FEV₁) 75.6 ± 17.4% predicted]. We applied a data-driven analysis pipeline, which enabled identification of protein signatu

SUBMITTER: DiLillo KM 

PROVIDER: S-EPMC10203309 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature