Themis suppresses the effector function of CD8⁺ T cells in acute viral infection.

ABSTRACT: CD8⁺ T cells play a central role in antiviral immune responses. Upon infection, naive CD8⁺ T cells differentiate into effector cells to eliminate virus-infected cells, and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved. Although extensively investigated, the underlying mechanisms of CD8⁺ T-cell differentiation remain incompletely understood. Themis is a T-cell-specific protein that plays critical roles in T-cell development. Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8⁺ T-cell homeostasis, cytokine responsiveness, and antibacterial responses. In this study, we used LCMV Armstrong infecti

SUBMITTER: Tang J 

PROVIDER: S-EPMC10203318 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature