Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets.

ABSTRACT: Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification, and noncoding RNAs modulate many biological processes that are crucial to the development of cancers. Dysregulation of the epigenome drives aberrant transcriptional programs. A growing body of evidence suggests that the mechanisms of epigenetic modification are dysregulated in human cancers and might be excellent targets for tumor treatment. Epigenetics has also been shown to influence tumor immunogenicity and immune cells involved in antitumor responses. Thus, the development and application of epigenetic therapy and cancer immunotherapy and their combinations may have important implications for cancer treatment. Here,

SUBMITTER: Yang J 

PROVIDER: S-EPMC10203321 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature