Parallel evolution of two AIM24 protein subfamilies and their conserved functions in ER stress tolerance in land plants.

ABSTRACT: Despite decades of efforts in genome sequencing and functional characterization, some important protein families remain poorly understood. In this study, we report the classification, evolution, and functions of the largely uncharacterized AIM24 protein family in plants, including the identification of a novel subfamily. We show that two AIM24 subfamilies (AIM24-A and AIM24-B) are commonly distributed in major plant groups. These two subfamilies not only have modest sequence similarities and different gene structures but also are of independent bacterial ancestry. We performed comparative functional investigations on the two AIM24 subfamilies using three model plants: the moss Physcomitrium patens, the liverwort Marchantia polymorpha, and the flowering plant Arabidopsis thaliana. Intriguin

SUBMITTER: Guan Y 

PROVIDER: S-EPMC10203443 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature