Development and validation of a clinical cure marker based on negative lymph nodes for gastric cancer after gastrectomy.

ABSTRACT:

Objective

To explore lymph node (LN)-related derived indicators as clinical cure markers for gastric cancer (GC) after gastrectomy.

Methods

Data of resected GC patients were extracted from the SEER database and our own department. Propensity score matching (PSM) was used to balance the baseline differences between the clinical cure and the nonclinical cure groups. The area under the curve (AUC) and decision curve analysis (DCA) were used to choose the optimal marker, and survival analysis was used to validate the clinical value of the most effective marker.

Results

After PSM, the differences in age, sex, race, location, surgical type, and histologic type between the two groups were significantly reduced (all P > 0.05), and the AUCs of examined LNs (ELNs), negative LNs

SUBMITTER: Xie J 

PROVIDER: S-EPMC10203492 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature