Investigation of heteroscedasticity in polygenic risk scores across 15 quantitative traits.

ABSTRACT: The polygenic risk score (PRS) could be used to stratify individuals with high risk of diseases and predict complex trait of individual in a population. Previous studies developed a PRS-based prediction model using linear regression and evaluated the predictive performance of the model using the R ² value. One of the key assumptions of linear regression is that the variance of the residual should be constant at each level of the predictor variables, called homoscedasticity. However, some studies show that PRS models exhibit heteroscedasticity between PRS and traits. This study analyzes whether heteroscedasticity exists in PRS models of diverse disease-related traits and, if any, it affects the accuracy of PRS-based prediction in 354,761 Europeans from the UK Bioban

SUBMITTER: Jung H 

PROVIDER: S-EPMC10203621 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature