MiR‑424‑5p is downregulated in the placentas of patients with preeclampsia and affects trophoblast migration and invasion.

ABSTRACT: Insufficient invasion of trophoblast cells has been reported to be closely associated with the pathogenesis of preeclampsia (PE). MicroRNAs (miRs) have essential roles in the trophoblasts invasion via targeting specific genes with diverse functions. However, the underlying mechanism remains largely unclear and requires further investigation. The present study aimed to identify and evaluate the potential functions of miRs in trophoblasts invasion and to reveal the underlying mechanisms. In the present study, differentially expressed miRs that were screened based on previously published microarray data (GSE96985) and a significantly downregulated miR-424-5p (miR-424) was chosen for further investigation. Subsequently, reverse transcription-quantitative PCR, CCK-8, apoptosis, wound healing an

SUBMITTER: Zhu W 

PROVIDER: S-EPMC10203755 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature