Detection of circulating tumor-derived material in peripheral blood of pediatric sarcoma patients: A systematic review.

ABSTRACT:

Background

Detection of circulating tumor-derived material (cTM) in the peripheral blood (PB) of cancer patients has been shown to be useful in early diagnosis, prediction of prognosis, and disease monitoring. However, it has not yet been thoroughly evaluated for pediatric sarcoma patients.

Methods

We searched the PubMed and EMBASE databases for studies reporting the detection of circulating tumor cells, circulating tumor DNA, and circulating RNA in PB of pediatric sarcoma patients. Data on performance in identifying cTM and its applicability in diagnosis, and evaluation of tumor characteristics, prognostic factors, and treatment response was extracted from publications.

Results

A total of 79 studies were assigned for the present systematic review, including detection

SUBMITTER: Kjær EKR 

PROVIDER: S-EPMC10203770 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature