Missense polymorphisms potentially involved in mandibular prognathism.

ABSTRACT:

Objective

The current study aimed to identify and analyze missense single nucleotide polymorphisms (SNPs) that can potentially cause mandibular prognathism.

Methods

After reviewing the articles, 56 genes associated with mandibular prognathism were identified and their missense SNPs were retrieved from the NCBI website. Several web-based tools including CADD, PolyPhen-2, PROVEAN, SNAP2, PANTHER, FATHMM, and PON-P2 were used to filter out harmful SNPs. Additionally, ConSurf determined the level of evolutionary conservation at positions where SNPs occur. I-Mutant2 and MUpro predicted the effect of SNPs on protein stability. Furthermore, to investigate the structural and functional changes of proteins, HOPE and LOMETS tools were utilized.

Results

Based on predictions in a

SUBMITTER: Kalmari A 

PROVIDER: S-EPMC10203774 | biostudies-literature | 2023 May-Jun

REPOSITORIES: biostudies-literature