Normalization effect of dopamine replacement therapy on brain functional connectome in Parkinson's disease.

ABSTRACT: Dopamine replacement therapy (DRT) represents the standard treatment for Parkinson's disease (PD), however, instant and long-term medication influence on patients' brain function have not been delineated. Here, a total of 97 drug-naïve patients, 43 patients under long-term DRT, and 94 normal control (NC) were, retrospectively, enrolled. Resting-state functional magnetic resonance imaging data and motor symptom assessments were conducted before and after levodopa challenge test. Whole-brain functional connectivity (FC) matrices were constructed. Network-based statistics were performed to assess FC difference between drug-naïve patients and NC, and these significant FCs were defined as disease-related connectomes, which were used for further statistical analyses. Patients showed better motor

SUBMITTER: Wu C 

PROVIDER: S-EPMC10203796 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature