The relationship between resting-state amplitude fluctuations and memory-related deactivations of the default mode network in young and older adults.

ABSTRACT: The default mode network (DMN) typically exhibits deactivations during demanding tasks compared to periods of relative rest. In functional magnetic resonance imaging (fMRI) studies of episodic memory encoding, increased activity in DMN regions even predicts later forgetting in young healthy adults. This association is attenuated in older adults and, in some instances, increased DMN activity even predicts remembering rather than forgetting. It is yet unclear whether this phenomenon is due to a compensatory mechanism, such as self-referential or schema-dependent encoding, or whether it reflects overall reduced DMN activity modulation in older age. We approached this question by systematically comparing DMN activity during successful encoding and tonic, task-independent, DMN activity at rest

SUBMITTER: Kizilirmak JM 

PROVIDER: S-EPMC10203811 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature