Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells.

ABSTRACT: Aged muscles accumulate satellite cells with a striking decline response to damage. Although intrinsic defects in satellite cells themselves are the major contributors to aging-associated stem cell dysfunction, increasing evidence suggests that changes in the muscle-stem cell local microenvironment also contribute to aging. Here, we demonstrate that loss of the matrix metalloproteinase-10 (MMP-10) in young mice alters the composition of the muscle extracellular matrix (ECM), and specifically disrupts the extracellular matrix of the satellite cell niche. This situation causes premature features of aging in the satellite cells, contributing to their functional decline and a predisposition to enter senescence under proliferative pressure. Similarly, reduction of MMP-10 levels in young satelli

SUBMITTER: Bobadilla Munoz M 

PROVIDER: S-EPMC10203875 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature