Association between inflammatory bowel disease and interleukins, chemokines: a two-sample bidirectional mendelian randomization study.

ABSTRACT:

Background

Mendelian randomization (MR) was used to evaluate the bidirectional causal relationship between inflammatory bowel disease (IBD) and interleukins (ILs), chemokines.

Methods

Genetic instruments and summary data of five ILs and six chemokines were obtained from a genome-wide association study database, and instrumental variables related to IBD were obtained from the FinnGen Consortium. Inverse variance weighting (IVW) was used as the main MR analysis method, and several other MR methods including MR-Egger and weighted median were used to confirm the reliability of the results. Sensitivity analyses such as heterogeneity and pleiotropy were also performed.

Results

The IVW method provided evidence to support that genetically predicted IL-16, IL-18, and CXCL10 si

SUBMITTER: Fang G 

PROVIDER: S-EPMC10203949 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature