The effect of oseltamivir use in critically ill patients with COVID-19: A multicenter propensity score-matched study.

ABSTRACT:

Background

Oseltamivir has been used as adjunctive therapy in the management of patients with COVID-19. However, the evidence about using oseltamivir in critically ill patients with severe COVID-19 remains scarce. This study aims to evaluate the effectiveness and safety of oseltamivir in critically ill patients with COVID-19.

Methods

This multicenter, retrospective cohort study includes critically ill adult patients with COVID-19 admitted to the intensive care unit (ICU). Patients were categorized into two groups based on oseltamivir use within 48 hours of ICU admission (Oseltamivir vs. Control). The primary endpoint was viral load clearance.

Results

A total of 226 patients were matched into two groups based on their propensity score. The time to COVID-19 viral load c

SUBMITTER: Aljuhani O 

PROVIDER: S-EPMC10203981 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature