Homotropic Cooperativity in Iron-Catalyzed Alkyne Cyclotrimerizations.

ABSTRACT: Enhancing catalytic activity through synergic effects is a current challenge in homogeneous catalysis. In addition to the well-established metal-metal and metal-ligand cooperation, we showcase here an example of self-activation by the substrate in controlling the catalytic activity of the two-coordinate iron complex [Fe(2,6-Xyl₂C₆H₃)₂] (1, Xyl = 2,6-Me₂C₆H₃). This behavior was observed for aryl acetylenes in their regioselective cyclotrimerization to 1,2,4-(aryl)-benzenes. Two kinetically distinct regimes are observed dependent upon the substrate-to-catalyst ratio ([RC≡CH]₀/[1]₀), referred to as the low ([RC≡CH]₀/[1]₀ < 40) and high<

SUBMITTER: Geer AM 

PROVIDER: S-EPMC10204060 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature