Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer.

ABSTRACT:

Significance

Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.

SUBMITTER: Nandi A 

PROVIDER: S-EPMC10204098 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature