Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study.

ABSTRACT:

Background

Poor medication adherence is common among bipolar patients.

Method

We examined prospective data from 2 cohorts of individuals from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study (1999-2005) with bipolar disorder. Clinical and sociodemographic features associated with missing at least 25% of doses of at least 1 medication were assessed using logistic regression, and a risk stratification model was developed and validated.

Results

Of 3,640 subjects with 48,287 follow-up visits, 871 (24%) reported nonadherence on 20% or more study visits. Clinical features significantly associated (P < .05) with poor adherence included rapid cycling, suicide attempts, earlier onset of illness, and current anxiety or alcohol use disorder. Nona

SUBMITTER: Perlis RH 

PROVIDER: S-EPMC10204120 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature