Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study.

ABSTRACT:

Background

Fatty acids are involved in a wide range of immunological responses in humans. Supplementation of polyunsaturated fatty acids has been reported to help alleviate symptoms and airway inflammation in asthma patients, whereas the effects of fatty acids on the actual risk of asthma remain controversial. This study comprehensively investigated the causal effects of serum fatty acids on asthma risk using two-sample bidirectional Mendelian Randomization (MR) analysis.

Methods

Genetic variants strongly associated with 123 circulating fatty acid metabolites were extracted as instrumental variables, and a large GWAS data of asthma was used to test effects of the metabolites on this outcome. The inverse-variance weighted method was used for primary MR analysis. The weighted

SUBMITTER: Huang T 

PROVIDER: S-EPMC10204212 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature