Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses.

ABSTRACT: High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst firings of hippocampal dentate GCs in synaptic plasticity remains unknown. We found that GCs with low input resistance could be categorized into regular-spiking (RS) and burst-spiking (BS) cells based on their initial firing frequency (F_init) upon somatic rheobase current injection, and investigated how two types of GCs differ in long-term potentiation (LTP) induced by high-frequency lateral perforant pathway (LPP) inputs. Induction of Hebbian LTP at LPP synapses required at least three postsynaptic APs at F_init higher than 100 Hz, which was met in BS but not in

SUBMITTER: Kim Y 

PROVIDER: S-EPMC10204231 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature