Effects of probiotics on pancreatic inflammation and intestinal integrity in mice with acute pancreatitis.

ABSTRACT:

Background

Severe acute pancreatitis is a potentially life-threatening disease. Despite being a common disorder, acute pancreatitis lacks a specific treatment. The present study aimed to examine the effects of probiotics on pancreatic inflammation and intestinal integrity in mice with acute pancreatitis.

Methods

Male ICR mice were randomly divided into 4 groups (n = 6 per group). The control group received two intraperitoneal (i.p.) injections of normal saline as a vehicle control. The acute pancreatitis (AP) group received two i.p. injections of L-arginine 450 mg/100 g body weight. AP plus probiotics groups received L-arginine to induce acute pancreatitis as above. In the single-strain and mixed-strain groups, mice received 1 mL of Lactobacillus plantarum B7 1 × 10⁸

SUBMITTER: Werawatganon D 

PROVIDER: S-EPMC10204250 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature