Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis.

ABSTRACT:

Background

Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer's disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity. Microglia are the immune cells in the central nervous system, sense the extracellular Tau via various cell surface receptors. Purinergic P2Y12 receptor can directly interact with Tau oligomers and mediates microglial chemotaxis via actin remodeling. The disease-associated microglia are associated with impaired migration and express a reduced level of P2Y12, but elevate the level of reactive oxygen species and pro-inflammatory cytokines.

Results

Here, we studied the formation and organization of various actin microstructures such as-podosome, filopodia and uropod in

SUBMITTER: Chinnathambi S 

PROVIDER: S-EPMC10204346 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature