Histone Demethylase Modulation: Epigenetic Strategy to Combat Cancer Progression.

ABSTRACT: Epigenetic modifications are heritable, reversible changes in histones or the DNA that control gene functions, being exogenous to the genomic sequence itself. Human diseases, particularly cancer, are frequently connected to epigenetic dysregulations. One of them is histone methylation, which is a dynamically reversible and synchronously regulated process that orchestrates the three-dimensional epigenome, nuclear processes of transcription, DNA repair, cell cycle, and epigenetic functions, by adding or removing methylation groups to histones. Over the past few years, reversible histone methylation has become recognized as a crucial regulatory mechanism for the epigenome. With the development of numerous medications that target epigenetic regulators, epigenome-targeted therapy has been used

SUBMITTER: Srivastava R 

PROVIDER: S-EPMC10204559 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature