The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells.

ABSTRACT:

Background

An increasing number of experimental and clinical studies show a link between Alzheimer's disease and heart diseases such as heart failure, ischemic heart disease, and atrial fibrillation. However, the mechanisms underlying the potential role of amyloid-β (Aβ) in the pathogenesis of cardiac dysfunction in Alzheimer's disease remain unknown. We have recently shown the effects of Aβ1 - 40 and Aβ1 - 42 on cell viability and mitochondrial function in cardiomyocytes and coronary artery endothelial cells.

Objective

In this study, we investigated the effects of Aβ1 - 40 and Aβ1 - 42 on the metabolism of cardiomyocytes and coronary artery endothelial cells.

Methods

Gas chromatography-mass spectrometry was used to analyze metabolomic profiles of cardiomyocytes and c

SUBMITTER: Jang S 

PROVIDER: S-EPMC10204711 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature