Analysis of ancestry-specific polygenic risk score and diet composition in type 2 diabetes

ABSTRACT:

Background

Carbohydrate and protein dietary proportions have been debated as to whether higher or lower levels are optimal for diabetes metabolic control.

Objective

The objective of this study was to investigate the associations, interactions, and mediational relationships between a polygenic risk score (PRS), carbohydrate and protein intake, and physical activity level on type 2 diabetes (T2DM) by genetic ancestry, in European Americans and African Americans. A secondary objective examined the biological pathways associated with the PRS-linked genes and their relationships to dietary intake.

Methods

We performed a cross-sectional study in 9,393 participants: 83.3% European Americans and 16.7% African Americans from 7-NHLBI Care studies obtained from the database

SUBMITTER: Hardy D 

PROVIDER: S-EPMC10204962 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature