Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion.

ABSTRACT:

Background

End-ischemic ex situ normothermic machine perfusion (NMP) enables assessment of donor livers prior to transplantation. The objective of this study was to provide support for bile composition as a marker of biliary viability and to investigate whether bile ducts of high-risk human donor livers already undergo repair during NMP.

Methods

Forty-two livers that were initially declined for transplantation were included in our NMP clinical trial. After NMP, livers were either secondary declined (n = 17) or accepted for transplantation (n = 25) based on the chemical composition of bile and perfusate samples. Bile duct biopsies were taken before and after NMP and assessed using an established histological injury severity scoring system and a comprehensive immunohistochemic

SUBMITTER: de Jong IEM 

PROVIDER: S-EPMC10205124 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature