Periaqueductal gray matter and medial prefrontal cortex reflect negative prediction errors during differential conditioning.

ABSTRACT: Computational models of associative learning posit that negative prediction errors (PEs) arising from the omission of aversive outcomes weaken aversive Pavlovian associations during differential conditioning and extinction. It is possible that negative PEs may underlie exaggerated conditioned responses to the conditioned stimulus not paired with an aversitve outcome (CS-) during differential conditioning and to the conditioned stimulus originally paired with a aversive outcome (CS+) during extinction in patients with clinical anxiety disorders. Although previous research has demonstrated that manipulations of the periaqueductal gray matter (PAG) interfere with extinction learning in animals, the role of the PAG in processing negative PEs within the human brain is presently unclear. We set

SUBMITTER: Gorka AX 

PROVIDER: S-EPMC10205175 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature