Ontology highlight
ABSTRACT:
SUBMITTER: Valenti M
PROVIDER: S-EPMC10205182 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Open biology 20230524 5
Gasdermin D (GSDMD) and mixed lineage kinase domain-like protein (MLKL) are the pore-forming effectors of pyroptosis and necroptosis, respectively, with the capacity to disturb plasma membrane selective permeability and induce regulated cell death. The budding yeast <i>Saccharomyces cerevisiae</i> has long been used as a simple eukaryotic model for the study of proteins associated with human diseases by heterologous expression. In this work, we expressed in yeast both GSDMD and its N-terminal do ...[more]