Glycans in spent embryo culture medium are related to the implantation ability of blastocysts.

ABSTRACT:

Research question

Does glycan profile in spent blastocyst culture medium have the potential to be used as a biomarker to predict implantation outcome.

Design

A nested case-control study was conducted in Northwest women's and children's Hospital, Xi'an, China. The patients underwent fresh IVF/ICSI cycles with single blastocyst transfer were included. Total 78 cases were included and separated into groups according to success (n = 39) and failure (n = 39) implantation outcomes. The glycosylation patterns in spent blastocyst culture medium were detected by lectin microarray containing 37 lectins using pooled samples and confirmed by reversed lectin microarray using individual sample.

Results

Binding signals of 10 lectins were found to be different between samples from su

SUBMITTER: Wang D 

PROVIDER: S-EPMC10205493 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature