PH-sensing hybrid hydrogels for non-invasive metabolism monitoring in tumor spheroids.

ABSTRACT: The constant increase in cancer incidence and mortality pushes biomedical research towards the development of in vitro 3D systems able to faithfully reproduce and effectively probe the tumor microenvironment. Cancer cells interact with this complex and dynamic architecture, leading to peculiar tumor-associated phenomena, such as acidic pH conditions, rigid extracellular matrix, altered vasculature, hypoxic condition. Acidification of extracellular pH, in particular, is a well-known feature of solid tumors, correlated to cancer initiation, progression, and resistance to therapies. Monitoring local pH variations, non-invasively, during cancer growth and in response to drug treatment becomes extremely important for understanding cancer mechanisms. Here, we describe a simple and reliabl

SUBMITTER: Rizzo R 

PROVIDER: S-EPMC10205545 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature