A strategy for low-cost portable monitoring of plasma drug concentrations using a sustainable boron-doped-diamond chip.

ABSTRACT: On-site monitoring of plasma drug concentrations is required for effective therapies. Recently developed handy biosensors are not yet popular owing to insufficient evaluation of accuracy on clinical samples and the necessity of complicated costly fabrication processes. Here, we approached these bottlenecks via a strategy involving engineeringly unmodified boron-doped diamond (BDD), a sustainable electrochemical material. A sensing system based on a ∼1 cm² BDD chip, when analysing rat plasma spiked with a molecular-targeting anticancer drug, pazopanib, detected clinically relevant concentrations. The response was stable in 60 sequential measurements on the same chip. In a clinical study, data obtained with a BDD chip were consistent with liquid chromatography-mass spectrometry re

SUBMITTER: Saiki T 

PROVIDER: S-EPMC10205593 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature