DDX58 Is Associated With Susceptibility to Severe Influenza Virus Infection in Children and Adolescents.

ABSTRACT:

Background

Seasonal influenza virus infection causes a range of disease severity, including lower respiratory tract infection with respiratory failure. We evaluated the association of common variants in interferon (IFN) regulatory genes with susceptibility to critical influenza infection in children.

Methods

We performed targeted sequencing of 69 influenza-associated candidate genes in 348 children from 24 US centers admitted to the intensive care unit with influenza infection and lacking risk factors for severe influenza infection (PICFlu cohort, 59.4% male). As controls, whole genome sequencing from 675 children with asthma (CAMP cohort, 62.5% male) was compared. We assessed functional relevance using PICFlu whole blood gene expression levels for the gene and calculated IF

SUBMITTER: Lee S 

PROVIDER: S-EPMC10205622 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature