Methylome changes associated with functional movement/conversion disorder: Influence of biological sex and childhood abuse exposure.

ABSTRACT: Epigenetic changes, such as DNA methylation (DNAm), may represent an important mechanism implicated in the etiopathogenesis of functional movement/conversion disorder (FMD). Here, we aimed to identify methylomic variations in a case-control cohort of FMD and to uncover specific epigenetic signatures associated with female sex and childhood abuse, two key risk factors for FMD and other functional neurological disorders. Genome-wide DNAm analysis was performed from peripheral blood in 57 patients with FMD and 47 healthy controls with and without childhood abuse. Using principal component analysis, we examined the association of principal components with FMD status in abused and non-abused individuals, in the entire study sample and in female subjects only. Next, we used enrichment pathway an

SUBMITTER: Spagnolo PA 

PROVIDER: S-EPMC10205664 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature