The prognostic value of tumour-infiltrating lymphocytes, programmed cell death protein-1 and programmed cell death ligand-1 in Stage I-III triple-negative breast cancer.

ABSTRACT:

Background

Tumour-infiltrating lymphocytes (TILs) represent a robust biological prognostic biomarker in triple-negative breast cancer (TNBC); however, the contribution of different subsets of immune cells is unclear. We investigated the prognostic value of immune markers, including stromal TILs (sTILs), CD8⁺T and FOPX3⁺T cells, PD-1 and PD-L1 in non-metastatic TNBC.

Methods

In total, 259 patients with Stage I-III TNBC were reviewed. The density of sTILs along with the presence of total (t), stromal (s), and intratumoral (i) CD8⁺T cells and FOPX3⁺T cells were evaluated by haematoxylin and eosin and immunohistochemical staining. Immunohistochemical staining of PD-1, PD-L1 was also conducted.

Results

All immune markers were pos

SUBMITTER: Sun GY 

PROVIDER: S-EPMC10205737 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature