Evaluation of instrumental variable method using Cox proportional hazard model in epidemiological studies.

ABSTRACT: The instrumental variable (IV) method with a Cox proportional hazard (PH) model has been used to evaluate treatment effects in epidemiological studies involving survival data. The effectiveness of the IV methods in these circumstances has yet to be fully understood, though. The study aimed to evaluate the performance of IV methods using a Cox model. We evaluated the validity of treatment effects estimated by two-stage IV models using simulated scenarios with varying confounder strengths and baseline hazards. Our simulation demonstrated that when observed confounders were not taken into account in the IV models, and the confounder strength was moderate, the treatment effects based on the two-stage IV models were similar to the true value. However, the effect estimates diverged from the true

SUBMITTER: Uddin MJ 

PROVIDER: S-EPMC10205781 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature