Sertraline treatment influences [¹⁸F]FE-PE2I PET imaging for Parkinsonism.

ABSTRACT:

Background

The dopamine transporter (DaT) PET ligand [¹⁸F]FE-PE2I is used to aid the diagnosis of Parkinson's disease. After encountering four patients with a history of daily sertraline use, who all showed atypical findings on [¹⁸F]FE-PE2I PET, we suspected that the selective serotonin reuptake inhibitor (SSRI), sertraline, might interfere with the results and lead to globally reduced striatal [¹⁸F]FE-PE2I binding due to sertraline's high affinity for DaT.

Methods

We rescanned the four patients with [¹⁸F]FE-PE2I PET after a 5-day sertraline pause. Sertraline plasma concentration was estimated based on body weight and dose, and specific binding ratios (SBR) in caudate nucleus, known to be more preserved in Parkinson's, were used to

SUBMITTER: Justesen TEH 

PROVIDER: S-EPMC10205964 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature