Immunoglobulin E-virus phenotypes of infant bronchiolitis and risk of childhood asthma.

ABSTRACT:

Background

Bronchiolitis is the leading cause of infant hospitalization in U.S. and is associated with increased risk for childhood asthma. Immunoglobulin E (IgE) not only plays major roles in antiviral immune responses and atopic predisposition, but also offers a potential therapeutic target.

Objective

We aimed to identify phenotypes of infant bronchiolitis by using total IgE (tIgE) and virus data, to determine their association with asthma development, and examine their biological characteristics.

Methods

In a multicenter prospective cohort study of 1,016 infants (age <1 year) hospitalized for bronchiolitis, we applied clustering approaches to identify phenotypes by integrating tIgE and virus (respiratory syncytial virus [RSV], rhinovirus [RV]) data at hospitalizati

SUBMITTER: Shibata R 

PROVIDER: S-EPMC10205992 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature