CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting.

ABSTRACT:

Introduction

Hypoxia-induced neuronal damage is the primary cause of cognitive impairment induced by high-altitude exposure. Microglia play a crucial regulatory role in the central nervous system (CNS) homeostasis and synaptic plasticity. M1-type polarized microglia are suspected to be responsible for CNS injury under hypoxic conditions, but the exact molecular mechanism is still unelucidated.

Methods

CX3CR1 knock out and wide type mice were exposed to a simulated plateau at 7000 m for 48 h to construct the model of hypobaric hypoxia-induced memory impairment. The memory impairment of mice was assessed by Morris water maze. The dendritic spine density in the hippocampus was examined by Golgi staining. The synapses in the CA1 region and the number of neurons in the DG region

SUBMITTER: Wang X 

PROVIDER: S-EPMC10206058 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature