Combined regression score predicts outcome after neoadjuvant treatment of oesophageal cancer.

ABSTRACT:

Background

Histopathologic regression following neoadjuvant treatment (NT) of oesophageal cancer is a prognostic factor of survival, but the nodal status is not considered. Here, a score combining both to improve prediction of survival after neoadjuvant therapy is developed.

Methods

Seven hundred and fifteen patients with oesophageal squamous cell (SCC) or adenocarcinoma (AC) undergoing NT and esophagectomy were analysed. Histopathologic response was classified according to percentage of vital residual tumour cells (VRTC): complete response (CR) without VRTC, major response with <10% VRTC, minor response with >10% VRTC. Nodal stage was classified as ypN0 and ypN+. Kaplan-Meier and Cox regression were used for survival analysis.

Results

Survival analysis identified thr

SUBMITTER: Damanakis AI 

PROVIDER: S-EPMC10206077 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature