Nearly maximal information gain due to time integration in central dogma reactions.

ABSTRACT: Living cells process information about their environment through the central dogma processes of transcription and translation, which drive the cellular response to stimuli. Here, we study the transfer of information from environmental input to the transcript and protein expression levels. Evaluation of both experimental and analogous simulation data reveals that transcription and translation are not two simple information channels connected in series. Instead, we demonstrate that the central dogma reactions often create a time-integrating information channel, where the translation channel receives and integrates multiple outputs from the transcription channel. This information channel model of the central dogma provides new information-theoretic selection criteria for the central dogma rat

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC10206154 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature