APOBEC3B stratifies ovarian clear cell carcinoma with distinct immunophenotype and prognosis.

ABSTRACT:

Background

Ovarian clear cell carcinoma (OCCC) is a challenging disease due to its intrinsic chemoresistance. Immunotherapy is an emerging treatment option but currently impeded by insufficient understanding of OCCC immunophenotypes and their molecular determinants.

Methods

Whole-genome sequencing on 23 pathologically confirmed patients was employed to depict the genomic profile of primary OCCCs. APOBEC3B expression and digital pathology-based Immunoscore were assessed by performing immunohistochemistry and correlated with clinical outcomes.

Results

An APOBEC-positive (APOBEC+) subtype was identified based on the characteristic mutational signature and prevalent kataegis events. APOBEC + OCCC displayed favourable prognosis across one internal and two external patient

SUBMITTER: Long X 

PROVIDER: S-EPMC10206171 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature