Genetic variants in HFE are associated with non-alcoholic fatty liver disease in lean individuals.

ABSTRACT:

Background & aims

Around 20% of patients with non-alcoholic fatty liver disease (NAFLD) are lean. Increasing evidence suggests that lean NAFLD is a unique subtype of the disease. We aimed to explore the metabolic profile, genetic basis, causal risk factors, and clinical sequelae underlying lean NAFLD.

Methods

NAFLD was diagnosed by whole liver proton density fat fraction ≥5%. Whole liver proton density fat fraction and hepatic iron were quantified using magnetic resonance imaging in the UK Biobank. Individuals in this study were stratified according to the World Health Organization criteria of obesity, into lean, overweight, and obese. Mediation analysis, Mendelian randomisation analysis, and Bayesian networks were used to identify a risk factor or a clinical sequela of lean

SUBMITTER: Sun Z 

PROVIDER: S-EPMC10206181 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature