The passive diffusion improvement of Vitamin B₁₂ intestinal absorption by Gelucire that fit for commercialized production.

ABSTRACT: Vitamin B₁₂ (VB₁₂) is a vital micronutrient to maintain the normal state of the hematopoietic system. It must be obtained from the diet since the human body cannot synthesize it. Moreover, the absorption of VB₁₂ needs to be mediated by intrinsic factor on the gastrointestinal (GI) track. The abnormalities in the stomach or lack of such intrinsic factors may result in poor oral absorption of VB₁₂. However, the very advanced formulation strategies were generally very costly and still in the development stage. Thus, the objectives of the present study were to increase the VB₁₂ intestinal absorption by conventional excipients of Gelucire 44/14 (G44/14) or Labrasol, which could be potentially formulated as a cost effect balanced product. Th

SUBMITTER: Jia CQ 

PROVIDER: S-EPMC10206182 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature